Stress-induced Nuclear Bodies Are Sites of Accumulation of Pre-mRNA Processing Factors
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چکیده
منابع مشابه
Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors.
Heterogeneous nuclear ribonucleoprotein (hnRNP) HAP (hnRNP A1 interacting protein) is a multifunctional protein with roles in RNA metabolism, transcription, and nuclear structure. After stress treatments, HAP is recruited to a small number of nuclear bodies, usually adjacent to the nucleoli, which consist of clusters of perichromatin granules and are depots of transcripts synthesized before str...
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Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct cytoplasmic sites of mRNA degradation. In this study, we show that SGs and PBs are spatially, compositionally, and functionally linked. SGs and PBs are induced by stress, but SG assembly requires eIF2alpha phosphorylation...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2001
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.12.11.3502